Three closely linked and reciprocally imprinted gene pairs were also discovered, and their pattern of expression suggests transcriptional interference.
Our short-read transcriptome sequencing approach identified three pairs of closely linked and reciprocally imprinted genes in which the paternally expressed genes showed 100% monoallelic expression whereas the maternally expressed genes are only partially imprinted in neonatal brains.
IGF2 and H19 are closely linked and reciprocally imprinted, and epigenetic alterations in human cancers at an intergenic differentially methylated region (DMR) are associated with LOI of IGF2 and silencing at H19.
Recently, an imprinted gene cluster at 14q32 has been defined and includes two closely linked but reciprocally imprinted genes, DLK1 and GTL2, that have similarities to IGF2 and H19, respectively.
This results in a hierarchical architecture that closely reflects the neuroanatomical data described earlier; in fact, the primary cortical areas (M1 and A1) are reciprocally connected to their neighbouring secondary areas (PM and AB); these, in turn, are reciprocally linked to their respective association areas (PF and PB), which are also interconnected (via long-range cortico-cortical links).
Inflammation is reciprocally linked to oxidative stress, which has also been implicated in MI.
Diabetes and depression are reciprocally linked, but few studies modeled their interplay considering the influence of affective temperaments (AT) and demographic factors.
Such a plan would NOT look at arts and culture in isolation, but as being reciprocally linked to society; the arts and New York are one.
I offer a vision for the City where the arts and culture are not viewed in isolation but as being reciprocally linked with society, and where they can be included as solutions for other priority issues -- for instance, jobs and economic development, equality for all, safety, sustainability and resilience.
