Several studies have linked muscle activity with inhibition of tumor growth [18], [19], [20].
For example, the transcription factor NRF1 linked regulation of the formation of the energy dependent proteosome with mitochondrial biogenesis, while C/EBP linked muscle formation with adipose tissue formation and energy homeostasis.
Tendons and ligaments are not just mechanical ropes linking muscles to bone or bone to bone.
Tendons aim at linking muscles and skeleton, and have the twofold function of stabilizing joints and transmit muscular forces.
So, we're linking muscles in surgery, we're getting nerves to regenerate, we're inserting titanium shafts through the skin membrane into bone.
Tendons cells link muscles to the backbone of the organism, and Gcm expression in these cells is required for proper muscle attachment (Soustelle et al. 2004).
DOI: http://dx.doi.org/10.7554/eLife.02372.001 Tendons, the tough connective tissues that link muscles to bones, are essential for lifting, running and other movements in animals.
Therefore, a broader definition in which EMG is defined as the recording of the electrical phenomena that are associated with the first stage in the sequence of events that link muscle excitation with muscle contraction4 may be more appropriate.
Attempts to test this hypothesis using genetically modified mouse models have produced contradictory results and instead link muscle insulin resistance to excessive fat oxidation, acylcarnitine production, and increased mitochondrial H(2 O(2 -emitting potential.
PS integrin deficiency has in cell culture systems been linked to loss of sarcomeric structures [27], thus suggesting a role for integrins in linking muscle attachment sites with the actin-myosin contractile apparatus [27], [30], [31], [32].
