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These results show that both the HDACi TSA and the DNA demethylating agent 5-Aza can reactivate Ezrin expression, and link modifications at the Ezrin gene locus with its expression.
A proteomic analysis revealed that habituation to DCB is linked to modifications in several metabolic pathways.
However, mechanisms inducing such changes are underinvestigated and, probably, may be linked to modifications of the cell surface and/or interactions with the membrane.
As such, viruses are commonly used in materials science as scaffolds for covalently linked surface modifications.
Recent studies in human cells have directly linked chromatin modifications to cellular senescence.
However, CgA also shows ultradian variation, which does not appear to be linked to modifications of catecholamine release [ 36, 37].
Thus, the improvements in cardiovascular function that these investigators found may be linked to modifications of vascular or inflammatory biomarkers.
Changes in cell or tissue specificity of expression are often linked to modifications of non-translated regulatory regions.
In summary, the kinetics of placental and foetal growth altered by ART may be linked to modifications in various biological pathways, probably triggering the placental compensation phenomenon.
We generated phosphopeptide maps of the phosphorylated HAND1 using the methods described below and linked these modifications to changes in HAND1 biological function.
Gangliosides strongly control cell surface dynamics and signaling; therefore, it could be assumed that these alterations are linked to modifications of cell behavior acquired by the tumor.
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