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Lampropoulou, V. et al. Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation.
Further work is required to directly link inhibition of C1A targets to growth inhibition.
However, detailed understanding of the regulatory mechanisms linking inhibition of FAS to these anti-tumor effects remains elusive.
The downstream molecular events linking inhibition of mTOR (TORC1) to cell survival in the presented cell models needs further investigation.
The primary mechanism linking inhibition of hepatic sterol synthesis to reductions in LDL-C involves compensatory upregulation of sterol regulatory element-binding protein-2 (SREBP2 -dependent gene tranSREBP2 -dependentonse to reduced intracellular cholesterol levels [ 29].
HGF overexpression attenuated monocyte chemoattractant protein-1 (MCP-1) induction, predominantly in astrocytes; suppressed activation of caspase-1, -3 and -9; and, increased X chromosome-linked inhibition of apoptosis protein (XIAP) in the motoneurons of G93A mice.
9 One such case reported exome sequencing undertaken in a male child presenting at 15 months with intractable IBD; exome sequencing was used to successfully identify a causal mutation in the XIAP gene (X-linked inhibition of apoptosis gene) for which the child was hemizygous.
Ramaswamy, S. et al. Regulation of G1 progression by the PTEN tumour suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
It has been postulated that precipitation of asthma attacks by aspirin is linked to inhibition of COX activity and massive release of cysteinyl leukotriene into the airway.
This results in transcriptional activation of some promoters and is directly linked to inhibition of sumoylation of the transcriptional activators involved.
We have examined whether the motor dysfunction in conversion paralysis can be linked to inhibition of the motor system, or rather to enhanced self-monitoring during motor behavior.
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