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The findings extend genetic studies linking inactivation of NIK genes to enhanced susceptibility to geminiviruses and protein structural analysis of residues required for kinase activity.
For example, the map shown in Figure 3 includes p53 and Rb as examples of tumor suppressor proteins but does not link inactivation of these proteins to cell immortalization through escape of senescence.
Fanconi anaemia is caused by biallelic (or X-chromosome-linked) inactivation of 1 out of 13 FA genes (Bagby and Alter, 2006; Dorsman et al, 2007; Smogorzewska et al, 2007), including BRCA2 (FANCD1).
Expression analysis of large genes located in genomic instability regions suggest that cancer progression is linked to inactivation of different fragile-site genes [ 19].
Possibly, the massive hypertrophic phenotype of dKO mice might be caused by reduced multi-ubiquitination and degradation of total muscle proteins (linked to inactivation of MuRF1/2 E3-ubiquitin-ligase activities).
However, the observation by Kamada et al. directly links the inactivation of TOR to the activation of Atg1 kinase activity and in turn to autophagy initiation.
Cell-to-cell contact, long known to cause inhibition of proliferation, was linked to the inactivation of Yap.
Overexpression of CycG with an ubiquitous driver (da Gal4>UASS::CycG or Act::Gal4>UAS::CycG) suppressed the lethality induced by UAS::dsCycG3 suggesting that it was linked to specific inactivation of CycG and not to Off-target effects (table 1).
The bactericidal action of the quaternaries has been linked to the inactivation of energy-producing enzymes, denaturation of essential cell proteins, and disruption of cell membranes [ 41].
Interestingly, the sensitivity of cells expressing FGFR2K659E plus c-Myc to apoptosis was linked to robust inactivation of ERK1/2, which did not occur in cells expressing FGFR2K569E alone.
This confirmed that the inhibition of PCD recorded in H2AX−/− MEFs is exclusively linked to the inactivation of the nuclear features characterizing MNNG-mediated necroptosis.
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