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Matrices were developed that linked determinants of behaviour change to performance objectives resulting in change objectives that were then mapped to CWH tools that are the basic elements of the intervention.
Autoreactive T-cell help is critical in epitope spreading [ 5], and immunization with an immunodominant T-cell epitope, generating autoreactive T cells, can stimulate autoreactive B cells reactive with intermolecularly linked determinants [ 6].
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Different approaches have been suggested to link determinants with strategies, from theory-based [ 28] to more pragmatic "common sense" approaches [ 29, 30].
[[ 5], p. ix] In order to do this, the Guide develops conceptual models linking determinants of public health problems, interventions for change, intermediate outcomes such as behavioral change, and health.
By avoiding this, health policies in the European Union (see Introduction) remain transterritorial policies as long as they influence the determinants of health in a specific transnational territory; and do not become global (read: supraterritorial) ones per definition as long as the health policies do not link determinants anywhere in the world.
Intervention components were linked to determinants and targeted the chosen change objectives.
First, the health of the population is linked to determinants of health such as improved sanitation, drinking water and cooking fuel.
To integrate results of FGDs and literature review, themes derived from the FGDs were linked to determinants of maintained behaviour found in literature.
In the same way, no decline in resistance against co-trimoxazole was observed in the United Kingdom even 10 years after it abandoned its prescribing, which in this instance was attributed to the co-selection of genetically linked resistance determinants by alternative antimicrobial pressure (24 ).
This work raised a lot of excitement as it suggested that phosphorylation of LKB1 at Ser was a focal point of a signalling network that linked extracellular determinants of neuronal morphogenesis through a cascade of at least five kinases, TrkB (tropomyosin-related kinase B), PKA, LKB1, SAD-A and SAD-B, to effectors that polarize neurons [ 37, 38].
House [ 5] presents a theoretical model linking social determinants with health.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com