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Then they linked copies of the mediocre ribozyme to 76-base RNAs with random sequences, hoping that one of the combinations would produce the key ribozyme.
Pairing may be accomplished by proteins binding to identical sites in linked copies, which subsequently form homodimers that strengthen chromatin association [36], [38], [39], [46].
These organisms encode two closely linked copies of NifHEN-like sequences in their genomes.
Linked copies will segregate as a single copy and will therefore not be noticed in Mendelian segregation studies.
However, multiple inserted copies (either linked or unlinked) have been implicated in issues with transgene silencing [ 5] and are not suitable for lines being considered for deregulation, indicating a need to identify linked copies.
In T0 plants with multiple copies, back-crossings may be necessary to achieve a single-copy generation (not tested), although this will not work if the plants carry linked copies.
Similar(47)
There is a closely linked copy number variation that may also contribute to resistance [8].
In the present study we provide evidence for the existence of an X linked copy of the AP3 gene.
To protect copyrighted content against unauthorized redistribution, distributors commonly embed watermarks or fingerprints in the content, uniquely linking copies to individual users.
This approach of linking copy number and drug induced expression changes may be a viable approach to identify particularly important genes for tumor progression.
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