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Consistently, in the present work the benzimidazole based para-xylyl linked iso-propyl-substituted complex (13) demonstrated higher cytotoxicity with IC50 9.7 μM, whereas the ortho- as well as meta- xylyl linked complexes (11 and 12) demonstrated comparatively moderate activities.
A common theme of autoantigens in SLE is their association in intermolecularly linked complexes associated with nucleic acids.
One recent innovation is the Cross-Linking ImmunoPrecipitation (CLIP); CLIP exploits photoreactive residues in RNA and polypeptides to generate covalently linked complexes.
Thrombospondin-1 is an adhesive protein released from activated platelets where it forms disulphide linked complexes with thrombin and thrombin-serpin complexes [ 63].
By comparing the resulting network of linked complexes before and after the addition of predicted interactions, we can see which links are a direct result of our predicted interactions.
The serum half-life of antibody-hapten conjugates and complexes was analyzed by determination of Cy5 fluorescence in mouse serum 0.08, 2, 24, 48, and 72 hours after intravenous application of the compounds (Fig. 7 ): covalent linkage increased the serum half-life of the payload in animals in comparison with noncovalently linked complexes.
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Set amid jagged black lava, Porto Moniz isn't just a pool, it's a whole linked complex of them.
It has been found that the conformation of the BSA does not change significantly during the chain interaction between BSA and chitosan forming the non-covalently linked complex.
The latter case yields a permanently covalently linked complex between the gliadin and the tTg.
These genes are usually organized into a tightly linked complex defined by three regions or classes.
The observed pattern itself is incompatible with features of a natural mutational process that would never change linked complex arrays of point mutations back and forth.
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