Defective proteasome activity is connected to the early phase of AD characterized by synaptic dysfunction, as well as to late AD stages linked to accumulation and aggregation of ubiquitinated (Ub) proteins in both senile plaques and NFTs.
Our studies on the transcriptional patterns of citrus calli linked carotenoid accumulation with redox state, starch metabolism, and flavonoid/anthocyanin accumulation.
More recently Saxena et al. [ 16] linked the accumulation of A5C3 reactive mutant SOD1 to motor neuron toxicity in the G93A mouse model of ALS.
ANGPTL4 might therefore represent an additional connection between bone loss and both osteoporosis and diabetes, linked to accumulation of adipocytes in the bone marrow with age and therapeutic intervention with PPARγ-inducing agents, respectively (63, 64).
For example, in contrast to the proteostasis enhancement we observe following thermal stress in yeast, previous studies have linked the accumulation of protein aggregates to reduced proteostasis capacity in vivo (Broadley and Hartl, 2009).
It appears that our maize endosperm gene set is rather comprehensive and provides a good representation of the entire transcriptome including genes linked to accumulation of storage products and energy supply.
In atherogenesis, for example, ceramide accumulation is linked to aggregation of LDL, increased ROS, and promotion of foam cell formations [ 39].
Critically, we identify TRM cells as important drivers of the equilibrium state, in line with previous reports linking the accumulation of these cells with enhanced anticancer immunity in patients17,22,23,24,25,26 and mouse models12,13,14,26.
Some limiting factor other than choline acetyltransferase activity appears to link the accumulation of exogenous choline to acetylcholine synthesis during development.
It is known that PHAs are accumulated by pseudomonads mainly in response to unbalanced growth conditions such as a lack of nitrogen, which links PHAs accumulation to the stringent response (López et al. 2015).
In his influential work, The Protestant Work Ethic and the Spirit of Capitalism (1905), Weber links the accumulation of capital to God's grace.
