Ub dimers bearing K6-, K11-, and K48-linkages adopt primarily compact conformations, whereas M1- and K63-linked dimers are relatively open.
Review of most published data, however, describes linkage evidence primarily for Caucasian multiplex prostate cancer families identified in North America and/or Europe.
The sample consisted of small nuclear families (SNFs) originally collected for linkage studies (primarily full sibs, half sibs, and parents, generally no more than one parent per family) and unrelated individuals who were recruited in the Eastern US (CT, PA, MA, and SC).
The agarase hydrolyzed β-1,4-glycosidic linkages of agarose, primarily yielding neoagarotetraose and neoagarohexaose as the final products.
However, some linkages were developed primarily to serve some other purpose or no specific purpose at all.
According to the Kasahara et al. model [ 20], linkage group G primarily composes Dr14 and Olat10/14, with minor contributions to Dr15, and linkage group H contributes primarily to Dr10/15/21 and Olat13.
Carrot genetic linkage maps have primarily been developed with anonymous AFLPs and RAPDs that require no prior genomic information, but these techniques yield primarily dominant markers [ 6].
Linkage maps, based primarily on highly polymorphic, anonymous microsatellite markers, have been important for identifying chromosomal regions influencing economically important traits in cattle [ 1- 3].
Linkage was based primarily on patient name, date of birth (DOB), and Social Security Number (SSN) with patient sex, race, ethnicity, and residential zip code as additional linking variables.
The early genetic linkage maps were primarily based on RFLP or AFLP markers and due to the lack of polymorphism or the complexity of the multiple banding patterns with these markers, simple sequence repeat (SSR) or microsatellite markers were proposed and then evaluated for the construction of genetic linkage maps [ 4, 5].
