In further searching for the molecular linkage of how deletion of Bmpr1a in the pancreas impaired glucose homeostasis, we mined our transcriptomic dataset for genes encoding molecules for classical insulin processing and secretion (RAB27A, RAB3D, ABCC8, VAMP4, VAMP3, CAPN10, STX1A, STX4A, KCJN11, SLC2A2, STX1B, GLP1R, STX1-B and STXBP3).
However, use of such linkages raises questions of how to resolve discordant or missing diagnoses in the two data sources.
These linkages provide an example of how, in the words of Marshall (1890), "organization aids knowledge".
This supports the idea that the interaction between NEMO and RIPK1 is stabilized by Met1 linkages and reveals a mechanism of how OTULIN may affect NF-κB activation in response to TNFα stimulation.
This final case study does provide an example of how such linkage may be achieved.
Figures 5 and 6 show some examples of how this linkage has been exercised with an Improvised Explosive Devices (IED) serious game [46] and an Energy Infrastructure Security serious game [47].
Specific applications in establishing processing structure property linkages are discussed as representative examples of how data science can potentially transform the current practices in the materials design and development arena.
Further, in order to properly discuss the potential impacts, it is necessary for researchers to have a reasonable understanding of how the probabilistic linkage process works and the matching processes involved.
We identify four distinct mechanisms of how OTU DUBs achieve linkage specificity.
The themes are portrayed using a series of cause-and-effect linkages showing how the system ultimately "creates value" for the population [ 12, 13].
