On the other hand, complete linkage clustering with the same diameter correctly identifies the existence of 1 cluster (Figure 1b), by progressively merging clusters as long as they are within a cluster diameter (see Figure S3 for the progress of the complete linkage algorithm).
The "build" option was used to order markers within the linkage group, with the same 1000 1 stringency as for the RH map (PUK_LIKE_TOL set to 3.0).
Significant ROH frequently formed clusters at overlapping positions on the genome, which may indicate that they were in linkage disequilibrium with the same QTL.
75 This panel shares the CHRNA3/5 (15q25) loci with the 20 single nucleotide polymorphism panel (the single nucleotide polymorphisms are in tight linkage disequilibrium with the same allele frequency).
We also observed a significant association between SNP49 and α-cellulose in the linkage population with the same genotypic effect for this locus in association populations (Table 5 and Figure 4), suggesting that SNP49 may be a functional polymorphism that is in or near a locus involved in the control of α-cellulose content.
The identification of two independent families with linkage to the same locus indicates that this region may harbour a second major FTD-ALS gene.
If consecutive SNPs are in high linkage disequilibrium (LD) with the same QTL, then the effect of the QTL and the SNP model frequency will be distributed across all the SNPs in high LD with the QTL.
Two other parameters, R70 and Fd, mapped to a common region on chromosome II, whereas R50 and succinate production had a potential linkage on the same region with a LOD score just below the threshold.
This type of epilepsy was named ADPEAF (autosomal dominant partial epilepsy with auditory features) (Winawer et al., 2000), and additional families with similar symptoms confirmed linkage to the same region of chromosome 10 (Winawer et al., 2002).
9 Our study was concerned with internal data linkage (ie, linkage between the same individual recorded multiple times within a longitudinal record).
