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DF, an organochemically synthesized linkage variant, and five major Phase I metabolites were covalently coupled to carrier proteins.
The possible role of drug-metabolism and bioactivation was examined using five major Phase I metabolites and one linkage variant of DF as haptens.
Furthermore, basophils of all three selective DF-hypersensitive and provocation test-positive patients (#52, 53, and 58) were stimulated with the linkage variant, DF5der-HSA (Table S2).
The linkage criterion to determine the distance between sets of nsSNPs was defined according to the average linkage variant.
For ease of discussion, the analysis below is limited to results from the constrained SLG v2 strategy (the E linkage variant with the most links).
In contrast, the correlations of the HCA/K-means approach are rather low with a mean of 0.299 for the average linkage variant.
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No regions of sequence conservation common to all 12 linkage variants are evident within the IGS.
In the 'A' family, three linkage variants form a sub-family (A1a-A1c) while a fourth linkage is the sole member of the second sub-family (A2).
Of the seven E linkage variants tested in this study, four had both high PPV and consistent sensitivity across the four movement groups from hospital into RAC identified in Table 6.
Totally five types of overconstrained 5R and 6R linkages, including the generalized Goldberg 5R linkage, generalized variant of the L-shape Goldberg 6R linkage, Waldron's hybrid 6R linkage, isomerized case of the generalized L-shape Goldberg 6R linkage, and generalized Wohlhart's double-Goldberg 6R linkage, can be constructed by modifying this Bennett network.
For all but 1 of the 30 groups of variants, 97 100% of reads show linkage of variants within the group, supporting the hypothesis that these variants are part of a single genotype.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com