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Specifically, it discusses the notion of linkage value to demonstrate why the B2B phenomenon on the Internet is so significant.
In this the strength of the association between the two genes is dependent on D′ (linkage disequilibrium) and r (relative linkage) value.
BSA: Bulk segregant analysis; Indel: Insertion-deletion; PLP PCRR fragment length polymorphism; RIL: Recombinant inbred line; RFLP: Restriction fragment length polymorphism; SNP: Single nucleotide polymorphism; SRA: Single recombinant analysis; ULV: Unitless linkage value.
The large number of affected individuals available for study in these ALS/FTLD families increased the linkage value of these families, and consequently their power to find new genes.
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The proximity of linkage values, which are the product of cluster analysis, is used to determine the optimal sensor configuration.
Suggestive linkage values were also obtained at three additional chromosome regions: the number of clinical malaria attacks on chromosome 5p15 (LO D= 2.57, empirical p = 0.001, Dielmo) and 13q13 (LO D= 2.37, empirical p = 0.0014 Dielmo), and the maximum parasite density during asymptomatic infection on chromosome 12q21 (LO D= 3.1, empirical p<10−4, Ndiop).
We also quantified DNA band intensities to determine linkages as unitless linkage values (ULVs) (see Methods).
NL: no linkage (values < 1 in parametric analysis) Only a small fraction of families showed significant linkage values (p < 0.05) in these regions when NPLOD score per Family was calculated.
Nevertheless, the linkage of this group to other markers on BTA 11 is convincing with LOD linkage values up to 13.8 between the extreme marker KIAA0284 and the neighbouring markers on the BovGen RH map.
Secondly, in order to evaluate whether a map of closely spaced SNPs offers equal or higher power to detect linkage compared with the traditional approach based on STR-GWS, we compared the linkage values obtained along these six candidate regions.
As input data for Circos, the physical positions of markers on the Malus genome were divided by 4 × 105 to obtain a genetic distance equivalent to marker linkage values of the Malus consensus map [ 29].
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