We used the OHIP linkage to classify underlying respiratory disease status by using diagnostic codes submitted to OHIP by specialist physicians.
The structural diversity of SAs arises not only from different types of SAs but also from their linkage to the underlying glycan residues.
In general, hotspots refer to eight genomic regions (Table S3) that have been implicated in linkage studies to underlie seed size traits and show strong GWAS-based association, which is defined by regions containing significant association SNPs (P ≤ 10−5) linked (r ≥ 0.5) with ≥10 minor significant association (10−5 < P ≤ 10−3) markers for boundary setting, with seed size traits in our studies.
Here we describe the distribution of thermokarst landforms in the continuous permafrost zone of Arctic Alaska, analyze linkages to the underlying surficial geology, and discuss the vulnerability of different types of landscapes to future thaw.
Pay attention to underlying meanings.
In theory, linkage disequilibrium lasting longer than a few generations may be due to close physical linkage of underlying loci or strong selection on unlinked loci.
That is, while there may only be a single gene underlying a given linkage to disease, such perturbation events may in turn cause transcript abundances of hundreds of genes to change, and many of these same genes may capture information from multiple genetic loci associated with the same disease.
The possibility of being able to link records from completed studies to child records in the on-going DSS data provides an opportunity not only to monitor future mortality outcomes, but to also monitor linkages between underlying morbidity history and future mortality.
This may be due to genetic factors such as the pleiotropic effects of the same genetic locus or linkage disequilibrium among underlying loci, or to natural or conscious selection against unfit trait combinations (Falconer and Mackay 1996).
Even though some differences in the level of binding to various terminal Gal structures by C. jejuni 11168-GS grown at conditions that mimic mammalian and avian hosts were noted, there appeared to be no significant specificity requirement for a particular glycosidic linkage or underlying sugar.
