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Noteworthingly, a majority of pure BFIS families[14] [17] also showed linkage to the same ICCA genomic area.
It has been observed that trans-eQTLs form clusters, or 'hot-spots' [19], where mRNA levels of transcripts across the genome show linkage to the same genetic locus.
We have ascertained a large multigenerational family in Nova Scotia affected with SCCD in which we have confirmed linkage to the same general area of chromosome 1.
In the remainder of this work we focused on the two families that showed linkage to the same region on chromosome 16.
Interestingly, there was linkage to the same region of chromosome 2p with asymptomatic infection that was replicated in both villages with LOD scores >1.
The identification of two independent families with linkage to the same locus indicates that this region may harbour a second major FTD-ALS gene.
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a"Fit" refers to the degree to which the linkages refer to the same population and conditions.
Because a reference set of known interactions is not available for S. meliloti, here we consider as positive set those functional linkages belonging to the same COGs functional category [ 37, 60].
Alignment positions (Mb) of the linkage-mapped markers were plotted against their centiMorgan (cM) position in the linkage map, and if markers/ESTs from >1 linkage group aligned to the same 10x scaffold, then, the primary linkage group of that scaffold plotted is that of the majority of corresponding markers.
Data for each patient were anonymously and independently sampled without linkage of prescriptions to the same patient across pharmacies because patients in the Netherlands are usually loyal to a single pharmacy.
15 Statistical linkage of births to the same mother was provided by Data Linkage Western Australia, located in the Western Australian Department of Health.
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