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It is thus possible that the association seen with MM here may represent linkage to estrogen related effects, either through cross-regulation effects of the two genes or via linkage to another marker in the distal parts of ESR1 that does not show linkage to those markers we have already interrogated in this study.
We do not know if this increase in HIV diversity over time reflects direct selective pressure for evolution (e.g., a response to cytotoxic lymphocytes targeting gag or pol epitopes [50]), linkage to another region that is the target of selective pressure (e.g., antibody-induced selection of env epitopes), or natural accumulation of mutations in the HIV genome without selective pressure.
Soluble adaptors may either carry the desired function directly or require linkage to another element.
If the 17 nt deletion originated from a common ancestral allele of SMIM1, we would expect its strong linkage to another nearby genetic landmark.
It is possible, therefore, that some of the associations we found, such as that for CG33692, are caused by physical linkage to another gene that causes differences in eyestalk length.
Two independent linkage groups were accepted as linked if a marker on the end of one group showed a cross linkage to another marker on a second group through the " maximum linkages" function of JoinMap 4.0.
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The management and meaningful use of big imaging data and its linkage to other information sources is another challenge but also a huge opportunity for producing future discoveries that should lead to improved patient care and outcomes.
In addition to these, another 9 families were included due to linkage to the NPY receptors in T. rubripes.
In the process of NNK metabolism, a diazonium intermediate may be formed by loss of hydroxide from metabolic intermediate 4, and the carbonyl may displace N2 to form a cyclic oxonium ion, which may also react with the oxygen in the internucleotide linkages to form another type of phosphate adduct.
This study adds another compelling reason for early diagnosis of HIV infection and linkage to care and treatment.
Thus, while the theoretical approach by itself cannot provide an estimate of the total number of missed matches for a particular strategy, it provides a practical tool for estimating the gains and losses in moving from one linkage strategy to another, and therefore can assist in developing a preferred linkage strategy.
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