Sentence examples for linkage targeted from inspiring English sources

Figure  3 (adopted from [ 27]) shows what genetic variants that may be detected with three primary strategies (genome-wide linkage, targeted sequencing and genome-wide association).

For example, polyubiquitylation through K48 linkages target proteins for degradation by the proteasome while K63 polyubiquitylation is often involved in cell signaling.

Disaccharide compositional analysis revealed a decrease in the -GlcA-GlcNS6S unitherepresenting the cleavable linkage target for heparanase (Fig.  1d; peak 2), and an increase in trisulfated -IdoA2S-GlcNS6S disaccharide (Fig.  1d; peak 5), as previously ascribed to heparanase upregulation [ 11].

In fact, we recognize that it is difficult to disentangle associated complex phenotypes in a family-based linkage study targeted at one phenotype only at a time.

Although the proposed linkage areas target sensitive headwater species by design, the resulting web of connection across the landscape can be expected to benefit a host of forest-dependent species.

In addition, markers shown to have tight genetic linkage to target genes in interspecific mapping populations may lose their selective power when used in backcross programs based on interspecific derivatives.

Poly-ubiquitination via the K48 linkage generally targets substrates for degradation by the 26S proteasome and regulates essentially all aspects of cellular functions[ 15], whereas mono- and oligo-ubiquitination or poly-ubiquitination via the K63 linkage mediate non-degradative events controlling DNA repair, kinase activation, and endocytosis [ 16].

We show here that SCLC drug development should take into account CXCR4/STAT3 linkage to target more specifically the malignant cells; although JAK2/STAT3 seems to have a dominant function in anchorage-independent cell proliferation, it has a minor function in adhesive processes of SCLC cells where CXCR4 antagonists should prove more efficient.

However, given the comprehensive approach of our intervention package, the results of other experiences from similar settings are still highly applicable; for example, TBA linkage interventions targeting specific geographic areas with high MMRs with special attention paid to remote rural areas [ 22].

The best studied polyUb chain linkage, the K48-linkage, targets proteins for degradation by the proteasome [3] [5], whereas K63-linked polyUb chains seem to serve a non-degradative role in transcription activation and DNA damage [6], [7].

In particular, supply disturbance scenario in the study attempts to measure linkage between the targeted export sectors and employment, and their skill-type intensity.