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Changing the flexible thioether linkage in G1TE into the relatively rigid sulfoxide linkage secured a 4-fold increase in potency (4, IC50=6.5 μM).
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The instrument linkage was secured onto the pad hooks.
"This change is manifested in China's relationship with emerging markets and developing countries, which is essentially based on forging and enhancing trade linkages and securing new markets for Chinese investment".
To safely remove a window motor, the linkage arms should be secured in a vice before the springs and motor are removed.
With an effective means of generating the two key fragments 2 and 3 secured, their controlled linkage to construct the full 25-carbon backbone of leiodermatolide was now executed (Scheme 4).
Given that heterozygous loci were secured from 14 of the 16 linkage groups, with the addition of a further unlinked (unassigned) marker, the probability of these markers all becoming homozygous by chance is therefore: P = 0.515 = 0.000030517578125.
But, a considerable amount of snow leopard habitat and linkages are likely to remain resilient to climate change, and these should be secured.
DOI: http://dx.doi.org/10.7554/eLife.00828.009 The Ub C-terminal tail adopts an extended conformation, secured through an intermolecular β-sheet with the HECT β-strand leading to the covalent linkage with the catalytic Cys777.
Informed consent was secured.
NA secured the funding.
RSP secured funding.
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