Sentence examples for linkage search from inspiring English sources

The procedure starts with the selected sequences used as seed for Seed Linkage search in UniProtKB.

This comprises the largest post-BRCA1/2 linkage search effort in breast cancer families in the world to date.

In the initial genome-wide linkage search, marker D8S258 generated the highest two-point LOD score of 2.5 at theta = 0.

Thus, this collaboration has now collected 78 families for a linkage search, and several preliminary hints for linkage are currently being pursued further.

A genome-wide linkage search was performed on this family, leading to a significant linkage (Lod score = 12.4) between the chromosomal region 6q22.3-q24 and increased HbF expression [ 14, 15].

A recent genome-wide linkage search on 237 TGCT pedigrees, the largest series of TGCT families examined to date, identified several 'regions of interest' on chromosomes 2p33, 3p12, 3q26, 12q13 q21, 18q21 q23 and Xq27.

This would be a substantial undertaking (at least four-fold larger than the current linkage searches) but would be achievable with international collaboration.

The genomic linkage searches that mapped BRCA1 and BRCA2 would have had adequate power to map a third gene, had it been responsible for most or all of the remaining families, but in fact no further loci have emerged.

This can be done by using equally spaced markers to perform a global linkages search of the whole genome.

Linkage marker search and prime designation were performed in the way essentially same way as previously described (Liu et al. 2005; Zeng et al. 2011; He et al. 2012).

The initial unbiased scans for human modifiers have relied on genetic linkage to search for chromosome regions associated with alteration of age at neurologic onset from that expected based upon the CAG repeat length in the individuals tested.