Exact(7)
The design rationale of reduction-sensitive polymers and conjugates usually involves incorporation of disulfide linkage(s) in the main chain, at the side chain, or in the cross-linker.
Further, this figure illustrates that assumptions can be made for the model as well as optionally for the pre-processing, post-processing, additional applied model(s) and linkage(s) between models.
Evidently, the specificity of Orange II azoreductase toward azo linkage for dye decolorization was strongly dependent upon electron affinity (e.g., electron-withdrawing capability) of substituents near of azo linkage(s).
In addition, when the sulfonate or carboxyl group was ortho to azo bond, the decolorization rate significantly decreased compared to the para substituent to azo bond (e.g., p-MO > o-MO or p-MR_o-MR) likely due to steric hindrance near azo linkage(s) (Hsueh and Chen 2008).
However, there are distinct differences in the types of regulatory systems and the linkage(s) between regulatory modules.
The pathway of formation and fixation of the ancestral U3-U5 gene linkage(s) is unclear, but the linkage per se presumably was generated by random gene shuffling and perhaps maintained by a favorable effect on gene expression.
Similar(51)
We tested whether linkage-specific OTU DUBs could be used in analogy to DNA restriction enzymes to hydrolyze specific linkages in complex samples to reveal the linkage type(s) present in a ubiquitinated substrate.
The linkage specificity in OTU DUBs can be exploited in Ub chain restriction analysis, whereby linkage-specific DUBs are used to identify the linkage type(s) on a ubiquitinated protein.
Second, IBD relationships in the most important linkage group(s) will dominate genetic covariance between relatives, not the overall genomic or expected (pedigree-based) IBD relationships.
An improved dual-functional micellar carrier composed of a PEG shell and FTS core via a disulfide linkage (PEG5k-S-S-FTS2) was developed.
To facilitate the retention of the therapeutic activity of the carrier, FTS was coupled to PEG via a reduction-sensitive disulfide linkage (PEG5k-S-S-FTS2).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com