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Lack of reproducibility of linkage results in serially measured blood pressure data.
Bouchard C. Genetic epidemiology association and sib-pair linkage: results from the Quebec Family Study In Bray GA, Ryan DH (eds) Molecular and Genetic Aspects of Obesity.
Genetic linkage results in the preservation of homozygous segments in the genome that are produced as the result of genomic sharing, which can then be detected as runs of homozygosity (ROH).
Genome-wide association and linkage results provide constraints on the allele frequencies and effect sizes of susceptibility loci, which we use to interpret the voluminous candidate gene literature.
We have since genotyped several additional markers across the region, to refine the linkage results.
It is important to note this when interpreting the innovation linkage results.
The strongest FUSION 2 linkage results were on chromosomes 6 (maximum logarithm of odds score [MLS] = 2.30 at 95 cM) and 14 (MLS = 1.80 at 57 cM).
Specifically, our linkage results suggest that there is a prostate cancer susceptibility gene on chromosome 17 that is independent of ELAC2.
In a previously published genome-wide scan of 478 Finnish affected sibling pair (ASP) families (FUSION 1), the strongest linkage results were on chromosomes 20 and 11.
Our linkage results overlap two broad, previously-reported linkage regions: 8p23.3-p12 found in studies sampling largely families of European ancestry; and 11p11.2-q22.3 reported by a study of African-American families.
Moreover, linkage results for camptothecin-induced cytotoxicity were replicated across multiple datasets.
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