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This bias can lead to inaccurate record linkage outcomes as described previously [ 2, 8].
Hesse et al. 26 was the only review that statistically modelled the effect of control-group type (TAU versus active control), but in those cases where it was possible to conduct such moderator analysis (drug use and linkage outcomes) they found no significant associations.
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We thus select cases for which we know the true match status from the gold standard dataset and regress the record linkage outcome on individual characteristics using a logistic model.
Elements of both games appear in other stories; however, the linkage of outcomes is unique to Gawain.
There are also limited data that link CPE to improved clinical practice behaviours, which may influence the strength of the linkage to outcomes.
A further advantage is that the linkage to outcomes is done while blinded to exposure, in this instance the laboratory results.
Using only full name, sex and date of birth for record linkage, pregnancy outcomes were available for 1681 (89.3%) of women included in the study.
This result converges with the linkage mapping outcome, because the markers 057K22_3F2 and 077C13_3 were both located in linkage group NLL-10 at a distance of 1.2 cM.
All lifestyle covariates were defined and harmonized across cohorts before linkage to outcome data.
This study provides data to support the use of record linkage for outcome ascertainment in studies evaluating predictive tests.
If misclassification of gastroenteritis did occur, linkage with outcome is unlikely, since H. pylori infection status is not typically known.
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