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Whether the variants mentioned above contribute to the acquisition of HA binding to α-2,6 linkage needs to be determined by further experiments.
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Notably, a robust prebiotic synthesis of activated purine β-ribonucleotides, and then the oligomerisation of activated β-ribonucleotides to yield pure [5′→3′] phosphodiester linkages needs to be demonstrated.
Education-labor market linkages need to be explored carefully.
Linkages need to be cost-efficient, and should account for specific dispersal requirements of species.
In particular, the indicators for the measurement of bonds, bridges and linkages need to be adapted to each context in which social capital is to be measured.
Land-sea linkages need to be identified to design sustainable and synergetic systems of aquaculture and agriculture for the integrated management of coastal regions.
Crucially, cross-regional linkages need to be developed to facilitate the transition from one regional health authority's care to the next, where health care is not administered at a national level.
Therefore, the shift in allele frequency in the central region of the cline is often much less than 1 for neutral markers, and linkage disequilibrium needs to be corrected for the effect of introgression to estimate dispersal distance (Box 3B).
PKHD1 is the main gene in ARPKD, but there is compelling evidence for locus heterogeneity why results that are merely based on linkage need to be handled with some care.
In the context of epidemiological research the advantages and disadvantages of follow-up using routine record linkage need to be compared with active follow-up methods, such as questionnaires, or regular invitations to health checks.
When a haplotype causes both preferable and inferior phenotypes because of linkage drag, it needs to be split by recombination to create a new desirable haplotype.
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