Sentence examples for linkage models from inspiring English sources

Incorporation of the linkage models, therefore, is expected to be valuable in the rational engineering of noncovalently oligomeric ligands.

The type of linkage information available varied from state to state, necessitating linkage models tailored to each state's datasets and resulting in varying linkage rates.

We apply the linkage models to the binding data for two published noncovalently oligomeric ligands: one targeting a small molecule (phosphocholine) and the other targeting a soluble protein (tumor necrosis factor α).

The linkage models provide a quantitative measure of the potential and realized enhancement in affinity that could inform and guide design optimization efforts, and they reveal physical insight that would elude model-free analysis.

To better understand the thermodynamic linkage between enhanced receptor binding and self-assembly, we have developed linkage models for the three commonly encountered types of noncovalently oligomeric ligands: homofunctional oligomeric ligands, heterodimeric ligands that target a single receptor, and bispecific ligands that crosslink noninteracting receptors.

Both the joint linkage models and the biparental linkage models in families C and E place the Dw3 QTL much farther away from the causal mutation.

Self-Help Group-Bank Linkage Model.

Gene-wide association testing was performed using measured genotype analysis, embedded in a variance component-based linkage model [28].

In this paper, we present a Bayesian linkage model that offers directly interpretable posterior densities or Bayes factors for linkage.

Thus experimental data for metal-matrix composites agree well with the predictions of the micro-crack linkage model.

Simulation of passive motion predicted similar kinematics as reported previously in an analytical four-bar linkage model.