With respect to the latter, one can estimate using a linkage disequilibrium method that measures departures from expected proportions (Weir and Hill 1980; Waples 1991; Bartely et al. 1992).
Statistical analysis using the Ward linkage method showed that group 1 is significantly different in expression from the other three groups.
Probabilistic linkage is a method that utilizes personal and event information common to a pair of records to estimate the probability that the two records describe the same person and/or event [7, 15].
Mapping by admixture linkage disequilibrium, a method that detects ancestral risk alleles for disease in groups of individuals from recently mixed populations, resulted in the identification of a novel risk locus (i.e., myosin, heavy chain 9, non-muscle [MYH9]) [ 36].
SOLAR is a computer package based on the variance-component method that performs linkage analyses for quantitative traits in pedigrees of arbitrary size and complexity, and was applicable to this study's large, complex pedigree with inbreeding loops and multiple matings.
Both BRCA1 and BRCA2 genes were identified using linkage mapping in families, a method that has been successful in identifying many Mendelian disease genes.
By comparing these results with those implemented using more standard linkage methods, covariates that convey substantial information for the linkage analysis were found [ 122].
The advantage of the Bayesian strategy, in contrast to other linkage methods, is that the number of putative QTLs is not fixed a priori.
Another weakness of privacy preserving linkage methods is that the clerical review of potential but uncertain links is not possible with encrypted variables [ 49].> -wrap-foot> Tests were performed on Desktop Computer with Intel® Xeon® CPU, 4 cores, 64-bit, 3 GHz, 12 GB RAM, Windows 7 Professional 64 bit operating system.
