In particular, many of the linkage losses may be a consequence of the whole-genome duplication experienced in the S. cerevisiae lineage after the common ancestor of the yeasts analyzed here.
There was a significant linkage between loss of FDG metabolism and clinical endpoints of PFS and OS.
Previous analyses have demonstrated that this strategy results in an ideal set of ∼27,000 genome-wide SNPs for linkage without loss of information.
Single nucleotide polymorphisms (SNPs) are fast becoming the markers of choice for genome-wide linkage scans, loss of heterozygosity (LOH), comparative genomic hybridization (CGH) and whole-genome association studies [ 1].
In the F2 scan, Vra2 displayed suggestive linkage to neuronal loss after VRA.
This experimental result further highlights the importance of the genetic linkage between eye loss and the VAB sensory system.
However, stabilization of the cross-link by reduction of the Schiff base linkage resulted in loss of enzyme activity.
As schematized in figure 1, tunicates underwent not only gene losses in this cluster but also loss of linkage of its constituent genes.
Furthermore, additional reduction of the expected response is explained by the loss of linkage disequilibrium between the SNP and the QTL due to recombination.
Further, the high quality of Swedish national registers and the consistent use of the unique national registration numbers assigned to each person ensure correct linkage, thereby precluding selective loss to follow-up.
