Instead, he settled for rhetorical linkage -- "joint striving" and "intensive consultations on the interrelated subjects of offensive and defensive systems".
Bias and mean square error (in cM and cM) (with standard errors) of five fine-mapping methods: linkage analysis, joint association and linkage analysis, linkage disequilibrium decay, two-marker association, and an IBD method.
Sensitivity analyses of cumulative incidences, incidence rates, and their time trends were performed to test how (1) exclusion of all simultaneous bilateral operations and (2) inclusion of the 354 PJIs whose linkage to joint replacement data was uncertain, would affect the results of the original analyses.
When building an integrated linkage map for joint linkage mapping or joint association-linkage mapping, variation in recombination frequency among families is commonly observed in some chromosome regions [6].
To deal with the variation in recombination frequency across families in joint linkage mapping by a consensus linkage map, recombination frequencies were estimated from the observed crossovers in the fth family.
Both the joint linkage models and the biparental linkage models in families C and E place the Dw3 QTL much farther away from the causal mutation.
Colocalization of GWAS and joint linkage QTL provide increased confidence in QTL position, because these models incorporate linkage disequilibrium information at different levels.
Recent approaches that combine variance-components-based linkage analyses with joint tests of linkage in the presence of association for disentanglement of the linkage and association and the application of such methods to fine mapping are discussed.
Power from joint linkage mapping, despite being low, was slightly higher than that from individual family mapping.
Thus joint linkage mapping provides us with a promising approach to study the genetics of flowering time.
These results indicated that for joint linkage mapping, rare QTL are more difficult to detect than common QTL.
