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Linkage is done by perfect matching of the unique National Identification Card Number and verified by name.
Data extraction and data linkage is done by the Query workbench, which is used for the selection and flagging of patients in different databases and the associated data extraction process.
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The record linkage was done by using the unique person numbers assigned to all Finnish citizens in the 1960s and currently a few days after birth.
All linkage was done using a unique identifier (scrambled personal health identification number).
Creating pre-processing and encryption templates, encryption validation and probabilistic record linkage are done at the linkage site (site C).
The linkage was done for those respondents who had provided informed consent for such linkage (n=6606, 74%).
Linkage was done using NHS Number, patient surname, forename, date of birth, date of specimen, postcode and reporting laboratory.
Hierarchical clustering analyses with Euclidean distance metrics and complete linkage were done using J-Express 2011 (MolMine AS, Bergen, Norway).
Linkage was done, blind to vaccination and HBsAg status, by the program Reclink2 and by a separately written SQL program; consolidation of their findings was finalised before unblinding.
Linkage was done using four non-nominal common identifiers: age or date of birth (DOB), sex, serogroup, and diagnosing health unit.
All data linkages are done to ensure the confidentiality of study subjects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com