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The results support the linkage finding that some loci in the 12p13.33-12.1 and 17q12-q21.32 may contribute to gliomagenesis and suggest potential target genes underscoring linkage signals.
Within this convergence of peaks there was also a suggestive linkage finding for theta EEG power (LOD = 2.2).
No significant difference was detected in the genotype or allele distribution between cases and controls, suggesting that our linkage finding in South Indians does not extend to genetic association in an American population of mixed European ancestry.
Further sequencing and analysis of the region will be required to elucidate the basis of this linkage finding.
18 Orenstein and colleagues, however, failed to replicate this linkage finding in a different GORD family material.
However, the linkage finding was not robust in a genetic association follow-up study of CHD in the general United States population.
Similar(54)
A gene shown to be associated with many cases of schizophrenia or manic depression might also reduce stigma, aid in diagnosis, or be used as a screening tool, an application bound to be controversial, said Dr. Kendler, who with colleagues has reported linkage findings for schizophrenia on Chromosomes 5, 6, 8 and 10.
In addition, we replicated recent linkage findings on chromosome 20q13 for TB (p = 0.002).
On the basis of our early linkage findings, in a previous study, we genotyped SNPs in GABBR2 and found that seven of the 12 SNPs initially identified were significantly associated with ND [11].
With that said, we are still left with the problem of evaluating and interpreting linkage findings in the context of the unresolved, but certainly complex, genetic architectures of neuropsychiatric disease.
Our linkage findings corroborate those of Chourrout and co-workers [51] who used another genome sub-assembly method, described only by name (Marche à Droite (Màd)), to produce their own set of Nematostella contigs.
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