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This linkage file has been subsequently used for research.
A linkage file stored in an encrypted format is created when a dataset is processed.
The second linkage file was based on public domain information (the PMW file) (King and Marrett 1996).
The use of a disinterested party and maintenance of a linkage file are described in the HIPAA regulations.
While Data Coordinating Centers (DCCs) maintain 'linkage files' identifying which study biospecimen IDs belong to which study subject IDs, the shared data need an additional linkage file that allows these biospecimen IDs to be linked to the 'masked' IDs.
- IRB Director Other institutions had no existing mechanism to provide such a disinterested party and opportunity for maintaining a linkage file, which would permit re-identification to the disinterested party but not to the investigators.
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Two linkage files were used.
The Repository PI and staff undertook a campaign to remind extant and new biospecimen depositors of the crucial need for accurate and well maintained linkage files to be deposited along with their biospecimens.
Early in the operations of the Repository we discovered that some study DCCs did not include such linkage files with the study documentation when they archived data and biospecimens with the Repository.
These lessons involve: the folly of overly ambitious and complex database designs, the need to regularly remind coordinating centers of the need to scrupulously maintain and archive linkage files, the benefits of planning in advance to link study data to the consent documents that specify how these data may be used, and the value of well-conducted data set integrity checks.
The maximum LOD score for each chromosome for each trait was retained from three iterations of linkage mappings (File S3 and File S4).
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