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QL carried out the sequence, linkage, expression and association analyses and wrote the manuscript.
Through an extensive PubMed search and survey of recent review articles, we assembled a large list of genes or gene products with a confirmed or putative association with AMD resulting from genetic linkage, expression differences (RNA or protein) or localization to drusen in humans [ 15- 33, 40, 54- 110].
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To test the genetic linkage between expression of PDK1, HR46, reproductive anatomy, and social foraging, we collected 697 newly emerged backcross workers (see Materials and Methods).
The current study reports the first phase of a genomic convergence analysis of SCZ, which is intended to integrate linkage and expression studies.
Importantly, genomic convergence analysis provides a strategy to collectively interpret and employ the massive, disease-related data sets produced by unbiased (i.e. non-hypothesis driven) linkage and expression studies.
A demethylated pattern was observed at an earlier stage in the sorted CD25hi populations (Figure 6A), possibly due to FOXP3's linkage to expression of the IL-2R alpha chain (CD25) i.e. higher affinity to IL-2 and faster proliferative response.
Although the interaction between two complex biological systems (virus and host) is a function of multi-factorial events, the linkage of expression of ICP4 to the Ras pathway seems to direct the overall dynamics of this relationship, which is significantly influenced by Ras signaling.
We therefore hypothesised that there may be a potential linkage between expression of cell cycle inhibitors and apoptosis.
They pooled multiple source of information including association, linkage, gene expression, regulatory pathway, and literature search and found two unique network motifs that were enriched by MDD.
The synaptic function gene, MAGI1, has also been proposed as a putative candidate in a linkage and expression analysis by Lopez de Lara 2010 [ 32].
In this study we investigate the pattern of single nucleotide polymorphisms (SNPs) in genes for which the mRNA levels show cis-genetic linkage (gene expression quantitative trait loci mapping in cis, or cis-eQTLs) in segregating mouse populations.
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