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© 2007 Wiley-Liss, Inc. Genetic mapping studies often reveal a region of linkage containing a number of disease-associated polymorphisms.
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Adaptive evolution under linkage contains all of these processes, and the model developed in this article integrates positive and negative interference, background selection, and hitchhiking into a unified treatment of multiple interacting mutations.
Partial characterization of the botryosphaeran produced under the optimized conditions showed one type of polysaccharide with β-glycosidic linkages containing glucose as monosaccharide.
Species of Bradyrhizobium are able to produce cyclic glucans with β(1 → 6) and β(1 → 3) glycosidic linkages, containing 10 to 13 glucose residues [ 66].
Heparin lyase II is a heparinase with broad specificity that acts at linkages containing either (1 → 4 -α-L-IdoA or (1 → 4 -α-L-IdoA residues and accommodates many different sulfation patterns in these polysaccharides.
Energy for RNA synthesis comes from high-energy phosphate linkages contained in the nucleotide precursors of RNA.
The HA of the HK03 virus that preferentially binds to sialic acid receptors with α2,6-linked oligosaccharide linkages contains serine at residue 223 and the HA of the VN04 virus that prefers an avian-like receptor with α2,3-linked oligosaccharide linkages contains asparagine at this residue [30], [31].
It is of note that in a recent study of Saccharomyces cerevisiae segregants it was shown that genes having cis-linkage contained a higher frequency of SNPs in promoters and 3' UTR sequences [ 12].
Analysis of the genotyping data in haploids also revealed genetic linkage among some of the markers, allowing us to generate a linkage map containing 27 preliminary linkage groups that represent approximately 70% of the S. rosetta genome.
The linkage map consisted of 22 linkage groups, including 2 linkage groups containing markers from chromosome 14 (labeled 14a and 14b).
Inspection of the recombination frequency matrix for the corresponding male and female linkage groups revealed that the male linkage group contained two linkage groups joined through an apparently spurious linkage relationship due to a single marker.
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