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DBM conceived and supervised the study, including the data extraction and linkage components.
We specified that size-standardized lengths of each of the four linkage components were controlled by 4 independent loci (2 alleles at each locus).
To facilitate this reconstitution, we looked for a cancer cell line that lacks cavin-3, but expresses normal levels of all other linkage components.
While many cancer cell lines lack cavin-3 (Xu et al., 2001; Bastiani et al., 2009; Lee et al., 2011), some lines such as PC-3 lacked additional linkage components.
Loss of cavin-3 linkage components may cause lipodystrophy through selective death in adipocytes (Martin et al., 2012); however, lipid mobilizing factors are elevated in the circulation of Cavin-3 KO animals (data not shown), suggesting that lipolysis is responsible for the loss of triglyceride stores.
In general, there are two ways to go for establishing the cooperation of a GIS and a DBMS: a) systems interoperability, i.e., coupling of pre-existing systems using linkage components; b) systems integration, i.e., design of a new system from scratch, which fuses all desired capabilities of individual technologies.
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The linkage component describes the fundamental element responsible for establishing relationships between nuclei across two time points.
The IDAT server now utilizes its record linkage component to decide whether to return an existing or a new PID.
The linkage component describes the dynamics of the relationships of nuclei between neighboring time points t and t + 1.
Our linkage component is closely related to the time dependence of a particle filter model, and is merely a modification with additional constraints.
In contrast, commonly seen modeling approaches either ignore the dynamic properties of enzymes by assuming they are constant or, without considering regulation, simply assign probability linkage among components through training sets.
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