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Exact(23)
The conserved haplotype around HWC2 locus that is observed in Hwc2-1 carriers might reflect the existence of linkage block adjusting to the environment of high latitudes.
A Japanese cultivar, Kogyoku, shows an example of conserved linkage block covering hwc2-2 and Xa1 surviving the selection in rice breeding history in Japan, where Hwc2-1 carrier temperate Japonica cultivars have been prevalent (Sato and Hayashi 1983).
We present these results to underscore the fact that the region surrounding rs2891168 and its linkage block has a complex pattern of variable splicing and expression change, and that any conclusions should be made cautiously.
It is possible that gene expression changes are only observed in immune cells, and that immune cells are central to the mechanisms of cardiovascular disease affected by rs2891168 and its linkage block.
We further defined an HCE-gene linkage block (HGLB) as a set of one or more HCEs related to the same (or the same group of) genes, resulting in 85 six-way conserved HGLBs (Supplemental Results S1).
This marker then became the first marker in the next linkage block, and the process was repeated until all makers were assigned to a linkage block.
Similar(37)
Regions associated with selective sweeps offer targets for future investigation aimed at identifying genes and alleles underlying the selection and breaking up extensive linkage blocks through recombination.
Despite the demonstrated value of wild rice introgressions (Ballini et al. 2007), rice breeders are often reluctant to disturb favorable linkage blocks which they have constructed over many years by crossing locally adapted cultivars with wild rice relatives.
Both work on genetic variations, but result from different processes, either by intentional crosses (QTL) or extant (GWAS), and the linkage blocks are of a different size due to the number of recombinations.
However, an allelic series could be detected in the larger linkage blocks of the segregating population.
Given that frequent breakpoints coincide with the position of ESAG3 loci between linkage blocks, these could play a role in orientating expression sites prior to the exchange of intervening regions.
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