Sentence examples for linkage association from inspiring English sources

Although, genome-wide studies, such as genetic linkage, association and expression, have allowed unbiased identification of candidate genes and pathways associated with AD development and progression, susceptibility loci or genes for AD with clinical significance have not yet been reported.

Here we discuss important issues in terms of alternative genetic strategies (linkage, association and/or cytogenetics) in the identification of candidate genes for the major psychoses.

Utilization of a number of sophisticated genetic approaches such as linkage, association and genome-wide association studies have enabled the identification of numerous genes and gene loci that have been linked to orofacial clefting.

These genes were selected by integrative evidence from linkage, association, gene expression and literature search.

Linkage, association and cytogenetic studies have supported the existence of a CL/P locus in the chromosome 4q31-ter region containing the PDGFC locus [70], [72], [73], [74].

Recently, genome-wide linkage, association and admixture mapping scans have detected risk loci on chromosomes 2p15, 3p12, 6q25, 7q21, 8q24, 10q11, 11q13, 17q12, 17q24, 19q13, 22q13 and Xp11 [3] (see also GWAS catalog: http://www.genome.gov/gwastudies/), although polymorphic variants in these regions seem to account for only a small proportion of the observed genetic predisposition to PCa.

Association mapping is increasingly being utilized to detect marker-QTL linkage associations using plant materials routinely developed in breeding programs.

Four of the significant linkage associations identified influenced the faecal egg count, and one chromosomal region was associated with the IgA serum indicator.

Some of the putative linkage associations reported here are consistent with previously reported QTL in cattle for similar traits.

Studies in dairy cattle examining the SCS have reported linkage associations on corresponding bovine orthologous regions, supporting the validity of our findings.

To the best of our knowledge, this study provides the first report of QTL for body conformation traits in dairy sheep; further studies will be needed to confirm and redefine the linkage associations reported herein.