However, to fully understand the explanatory or confounding factors and to incorporate them into a multivariate cox regression analysis, linkage is needed with more data sources.
However, a tight linkage of the ecological data with genome features of strain BS001 has been lacking so far, in spite of the fact that this linkage is needed to build hypotheses that are testable in further experiments.
Finally, setting both β CYP1A1 → RARB = 0 and β ALDH6 → RARB = 0 significantly shifts the distribution of the posterior log-likelihood to smaller values (10% reduction overall), suggesting that at least one of these linkages is needed to explain these data.
Further linkage studies are needed to definitively establish linkage of the PTPN22-1858T allele to RF+ RA.
High density genetic linkage maps are needed for marker assisted breeding but are not available for cowpea.
Moreover, dairy cattle results also indicated that several generations of linkage analysis are needed for high r G S G LA [ 7].
Further studies, perhaps using a linkage mapping approach, are needed to confirm whether the SNP markers are truly linked to previously undetected QTL for SSR resistance.
2 In the trial of self-testing from Philadelphia, PA, USA, 96% reported they would seek medical care if they tested HIV-positive, but prospective data on the actual rates of linkage to care are needed.
Ultimately, GWAS is an indirect genetic mapping approach that relies on linkage disequilibrium, so further studies are needed to pinpoint functional variants by deep sequencing and functional molecular studies.
Many suicidal youths do not receive mental health care after discharge from the ED, and interventions are needed to enhance linkage to outpatient intervention.
