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The particular problem of genetic linkage analysis is used to illustrate and implement the architecture.
Efficient design of genome scans for linkage analysis is therefore an important issue.
Human linkage analysis is providing the localization of susceptibility loci distributed in chromosomes contributing to elucidate the manner in which interactions between these loci mediate SLE pathogenesis.
A much more serious limitation of ASP linkage analysis is the implicit assumption that randomly sampled sib pairs share half their alleles identical by descent at any locus, whereas a critical assumption underlying Vieland and Huang's proof is that of joint Hardy-Weinberg equilibrium proportions at two trait loci.
The application of recombinant DNA technology to linkage analysis is revolutionizing the gene mapping field through the availability of an increasing number of restriction fragment length polymorphisms (RFLP).
Linkage analysis is the method of choice when studying monogenic disorders, but linkage studies are difficult in case of oligogenic inheritance.
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Linkage analysis was used to place 51 of these loci into the existing rhesus linkage map.
Unsupervised clustering and heatmap generation with sorted datasets, using Pearson's correlation in Ward's method for linkage analysis, were performed using Partek Genomics Suite 6.6.
Linkage analysis was carried out under an autosomal dominant model for GLC1A glaucoma.
Genome-wide linkage analysis was performed for infarct volume as a quantitative trait.
Multipoint linkage analysis was performed using MAPMAKER Version 3.0 (Lander et al. 2009).
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