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There are precedents for intermediaries that link signaling pathways in different cells.
SAM68 belongs to the STAR (signal transduction and activation of RNA metabolism) family of RNA binding proteins (RBPs) that link signaling pathways to RNA processing [ 3, 4].
After brain damage, different signaling mechanisms operate to account for the variety of the retrograde responses occurring after injury, all requiring the involvement of sophisticated mechanisms that link signaling systems with intracellular transport machineries.
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Moreover, genes associated with integrins, glycoproteins, laminins, fibronectins, cadherins, selectins and linked signaling pathways were found.
α-Syntrophin is a scaffolding protein linking signaling proteins to the sarcolemmal dystrophin complex in mature muscle.
Cell surface receptor linked signaling pathway is another enriched process, indicating busy signal transduction during vascular formation.
Improvements in our understanding of matrix assembly, cross-linking, signaling and turnover will be required as well.
Such a strategy will require linking signaling pathways with a unifying set of biomarkers that can be detected by immunohistochemistry.
Analysis of our screening data reveals two linked signaling pathways with integrated roles in regulating ATP efflux: EGO (Exit from G0) and TORC1 (target of rapamycin complex 1).
Therefore, these two linked signaling pathways have been identified as important regulators of human prostate cancer cell invasion, and genistein induces anti-invasive effects on both pathways.
Diagnostic gene expression profiles linking signaling pathways to the different STS subtypes were demonstrated and a hypoxia-induced metastatic profile was identified in the pleomorphic, high-grade STS.
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