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Recent reports link resistance to conventional therapies and the metastatic potential to a stem-like tumour population, termed cancer stem cells (CSCs).
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To reduce the complexity of a full solution to the AC problem, the DC approximation assumes zero link resistances and no reactance dependence on link lengths.
Also ill-advised is a popular trope that links resistance to childhood vaccination with disbelief in evolution and doubt of climate change as instances of public "distrust in science".
Another hypothesis linking resistance to fitness is the inbreeding-infection hypothesis [11], [19], [20].
Existence of two closely linked resistance genes within the Scmv1 region has been postulated [ 18, 19].
Other approaches linking resistance to either dose or exposure need to be explored.
Linking resistance strength with increases in malaria transmission is currently not possible but is a key priority for further studies.
Recent studies have linked resistance to chemotherapy and radiotherapy in OSCC to altered miRNA expression and function.
We have previously linked resistance to growth control by TGF-β1 at the HKc/DR stage to reduced mRNA expression of TGFBR1 but not TGFBR2 [ 24].
Hence, linking resistance genes with resistance phenotypes will be more and more important for the understanding of why some isolates are extremely resistant and why some contain multiple resistance genes encoding resistance to the same antimicrobial classes.
Mapping of major Cry1A resistance genes has linked resistance to the ABCC2 locus in Heliothis virescens, Plutella xylostella, Trichoplusia ni and Bombyx mori, and mutations in this gene have been found in three of these Bt-resistant strains.
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