Exact(1)
Notably, ReL provides the same results when applied with or without Boneferroni correction for the gene variant association −log p values and link potentials scores, since the construction of the biclusters is robust to an additive rescaling of these scores.
Similar(59)
Notable examples are: "variant-gene associations" instead of eQTL; "linked relationships" instead of Pearson correlation and "link potential" instead of averaged correlation; "bipartite module" instead of pleiotropy.
In October 2005, I stumbled across a Web site called MatchingDonors.com that helps link potential donors and recipients.
For a percentage, brokers would link potential soldiers with communities offering high bounties, then bolt with the entire sum.
5) Linked relationships and link potential: In both cases, the term could not be replaced with an existing term.
Link potential is high (left) when the distributions of correlation differ between the high and low association range more than expected by chance; link potential is low (right) where no difference is observed.
DOI: http://dx.doi.org/10.7554/eLife.04346.008 10.7554/eLiFigure46.009 Figure 2 figure supplement 3. Higher link potential scores for real data than for permuted data.
Notably, a high link potential reflects the potential that some transcripts may translate between a variant and a trait, although such transcripts are not yet specified.
The holistic MPE approach enables us to link potential etiological factors to specific molecular pathologies, and gain novel pathogenetic insights on causality.
Briefly, the ReL algorithm starts with a set of seed clusters consisting of one trait and one variant whose link potential exceeds a certain initialization cutoff, c s.
Applying enrichment analysis on large-scale annotations data enables us to link potential biomarker with significantly altered TFs, miRNAs, and signal pathways.
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