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Together with SP, cilia may link mechanical responses to osteogenic processes in the absence of a canaliculi network.
The ciliary membrane contains receptors and ion channels that link mechanical or chemical stimuli including fluid flow, sonic hedgehog and growth factors to intracellular signaling cascades regulating cell differentiation, migration and growth.
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It is now important to functionally test the mechanisms linking mechanical stimulation with Wnt signalling.
If we can demonstrate in an appropriate assay system that the response is direct we open the possibility of revealing the cellular mechanisms that links mechanical stimulation with gene regulation.
Reviewer #1: In the manuscript "Piezo1 links mechanical forces to red blood cell volume" the authors investigate the molecular mechanism by which Piezo1 ion channel activity contributes to the dehydrating red blood cell disease Xerocytosis.
By combining data from the two steps an equation linking mechanical power (dependent on mass) to electrical power (calculated by multiplying voltage by current) can be derived.
Quantitative stability/flexibility relationships (QSFR) are readily evaluated because the DCM links mechanical and thermodynamic properties.
Based on the concept of effective bond density, scaling laws are developed for the elastic properties of β−graphyne, which demonstrate a useful approach for linking mechanical properties of graphene allotropes to those of graphene.
Thus, the present study demonstrates that myosin IIA and IIB with separate but linked mechanical roles determine the fate of lamellipodia extension during cell spreading.
5) Double-Pendulum (Movie S5): two linked mechanical plates freely oscillated back and forth at fundamental frequencies matched to those of Biological-Motion (frequencies of the upper and lower link of Double-Pendulum were matched with those of the head-trunk and lower limbs of Biological-Motion, respectively).
Piezo1 links mechanical forces to red blood cell volume.
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