While the authors describe in some detail previous studies linking expression levels to gene compactness in several organisms.
The converse also applies, as MAPKAPK2 knockout mice exhibit markedly reduced p38α protein expression [32], highlighting the intricate link between expression levels of these two molecules.
As GPER is suggested as an alternative oestrogen receptor, we further investigated a possible link between expression levels of GPER and ERs in the larger prospective validation series.
To try and understand whether we could link LETM1 expression levels with a specific mitochondrial deficit or a set of deficits, we investigated different aspects of mitochondrial function in these patient LCLs.
We, along with others, have previously worked to link gene expression levels to patterns of CUB by nesting a mechanistic model of protein translation into a population genetics model of allele fixation in order to estimate codon-specific mutation and selection parameters (Gilchrist and Wagner 2006; Gilchrist 2007; Shah and Gilchrist 2011; Wallace et al. 2013).
Other genes that encode enzymes in this pathway and that were identified in our study for their strong statistical link between expression levels and the production of specific compounds include LEU2, encoding a beta-isopropylmalate dehydrogenase that catalyzes the third step in the leucine biosynthesis pathway, and, to a lesser degree, LEU1, which encodes an isopropylmalate isomerase [ 22, 23].
One finding of the Jarinova et al. study is that the risk allele is linked to expression levels of ANRIL in whole blood cells from healthy human subjects.
Two competing models have been proposed to explain the lower overall X-linked gene expression levels in Drosophila testes.
The new parameters are easily expressed in terms of the original ones and of the coefficients of the affine transformations, but this is irrelevant practically since we will use microarray data to directly compute the new parameters for a CKE of type (1) linking recorded expression levels.
To this end, we applied a quantitative strategy to link the expression level of Hox genes with the enrichment of specific histone methylations in Hoxa9 regulatory region.
