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Exact(18)
In control animals, 4% of the lipid profile area in the surface lining layer was myelin figures (MF), 14% was tubular myelin, 37% was vesicular forms (VF), and the remainder (45%) was hypophase.
However, the lining layer was CD90-negative (in contrast to podoplanin).
Sema3A-immunostaining intensity per unit area of lining layer was significantly less in RA patients compared with OA.
Synovial necrosis was not identified in these pre-operative groups, although mild hyperplasia of the lining layer was observed.
In addition, the lining layer was positive for syndecan-3 suggesting that macrophages may also be positive in this layer, since macrophages are known to be a major component of the lining layer.
Development of a reactive neo-synovial membrane ranging from flat/micropapillary, especially in bursal specimens, to florid papillary hypertrophy, ranging from coarse to polypoidal configuration, with a variable amount of stromal cell proliferation and hyperplasia of the lining layer was observed in both series.
Similar(42)
In the same report, distinct synovial features such as increased fibrosis in the synovial tissue and a thicker synovial lining layer were found in anti-CCP RA patients [ 18].
The normal synovial lining layer is a condensed accumulation of cells one to four cells thick that resides between the fluid-filled joint cavity and a more loosely packed stroma [ 17] (Fig. 2).
Sections with nonassessable tissue, defined as the absence of an intimal lining layer, were not analyzed.
4 11 12 Sections with non-assessable tissue, defined by the absence of an intimal lining layer, were not analysed.
Sections with non-assessable tissue, defined by the absence of an intimal lining layer, were excluded from analysis.
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