In order to avoid interference of relay blocking with the main protection duty of distance relays, the proposed approach recognizes the minimum critical lines with the highest contribution in cascading failure for blocking zone 3 of their distance relays.
In this paper, based on the statistical activation of distance relays, a deterministic probabilistic approach is developed for identifying the critical lines with the highest contribution in blackouts due to activation of zone 3 of their distance relays.
Expansion lines with the highest copy number, BAC-Exp1 and BAC-Exp2, develop a severe, fully penetrant phenotype (see Supplementary Video 1 online, which shows a BAC-Exp2 animal at 20 weeks) in which animals become inactive, lose weight and die prematurely, with survival ranging from 4 18 months (Fig. 2a and Table 1).
Comparison of the original new plant type (NPT) lines with the highest yielding Indica rice cultivars has shown that the original NPT lines had significantly lower tillering capacity (Peng et al. 1994).
The expression levels varied among the cell lines, with the highest level seen in ES-D3 cells and the lowest level observed in ES-B6 cells.
The two lines with the highest DCF-DA fluorescence exhibited the highest degree of EGFR activation, as measured by levels of phospho-EGFR (Tyr 1173), phospho-Stat3, and phospho-ERK1/2 [27] (Fig. 3B).
For example, the transgenic lines with the highest RFP levels, such as miR-E1k15, miR-Scr105, miR-Scr109 and miR-Scr113, did not develop microcephaly, whereas the lines with low levels of RFP expression, such as miR-E1k32 and miR-Scr103, developed microcephaly (Table 1).
To verify the miRNA levels, we measured the transgene-encoded miRNAs by real time RT-PCR and confirmed that most transgenic lines with the highest miRNA levels did not develop microcephaly, whereas the lines with relatively low levels of miRNA did (Table 1).
Here, we identify compounds from the DTP database that are most active against cell lines with the highest take rate, and proceed to establish a putative mechanism of action for these compounds by performing structure-activity relationship studies, and comparing them to standard anticancer agents whose mechanism of action is known.
Interestingly, when these cell lines were analyzed for CEACAM6 gene variants, only T84 and HCT116 cells, the two cell lines with the highest and lowest CEACAM6 expression, respectively, had unique genotype variants when compared with the other cell lines (Fig. 2B).
As no clear distinction between a resistant and sensitive group of cell lines was detected, the 25% /50%/25%split described in the Materials and Methods Section was chosen, i.e. the five cell lines with the lowest GI50 values were denoted sensitive and the five cell lines with the highest GI50 values were denoted resistant.
