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These compounds exhibited potent cytotoxic effects on tumor cell lines, whereas it was less toxic to WI-38 cells than anticancer drug VP-16 or its parent compound norcantharidin.
However, to reduce morphological differences, cholera toxin was used exclusively during generation of the lines, whereas it was subsequently omitted for their analysis.
We found that MKK3 depletion strongly inhibited proliferation and survival of wtp53-bearing cancer cell lines, whereas it did not have any relevant effects on untransformed cells.
We show that LACE demonstrated a potent in vitro growth inhibition of several tumor cell lines, whereas it induced proliferation and activation of peripheral blood lymphocytes (PBLs).
Western blotting analysis showed that CENP-H protein was highly expressed in all cell lines, whereas it was weakly detected in normal esophageal tissue (Fig. 1).
In fact, the UbcH10 protein was abundantly expressed in all of the carcinoma cell lines, whereas it was barely detectable in normal thyroid cells.
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Fluorescence enhancement upon bisANS binding to DMPG-PDC-109 mixture was slightly higher than that observed for binding to native PDC-109 (dash dot dot line), whereas it was nearly 1.5-fold higher as compared to the enhancement observed for binding to native PDC-109 and 16.4-fold higher than control (buffer + bisANS), in the case of DMPC-PDC-109 complex (solid thick line).
TGF-β represses RUNX2 in an osteosarcoma cell line, whereas it induces RUNX2 in a myoblast precursor cell line.
TPX2 expression was not detected in the ACBRI515 human pancreatic epithelial cell line, whereas it was detected in all pancreatic cancer cell lines, including KLM1, KP4, Panc1, PK45H, PK8, PK9, and MIA Paca2 (Fig. 1D).
Lower levels are observed in D6 cell lines cells whereas it is undetectable in WT cell lines.
Total mortality in Taiwan was 22.8% and 23.6% for control and selected lines, respectively, whereas it was below 5% in France.
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