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Contour lines were calculated using R package kde2d.
IC50 values for the CRC cell lines were calculated using the XL fit 3™ software.
Solid lines were calculated using the measured values of KBS1, KBS2, and Kcoop, and dashed lines were calculated using the measured values of KBS1, KBS2, with Kcoop set to 1. Positive binding cooperativity for E2C-16 and E2C-11 has two linked effects.
The IC50 values of SSZ and DFMO for SK-N-Be(2 c and LAN-5 NB cell lines were calculated using the nonlinear log inhibitor versus normalized response curve fit function from GraphPad Prism 6 software (La Jolla, CA).
Pearson correlation coefficients for each pair of iPSC lines were calculated using the log2 RPKM values via cor function in R. DE genes between aneuploid iPSCs (T8, T13, T22, and XO) and normal iPSCs (UMC1 and UMC6) were identified by DEGseq, for which R-packages are available under Bioconductor (http://www.bioconductor.org/packages/2.7).
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The ice discharge flux across grounding lines is calculated using the rigorous flux gate method44 in combination with ice velocity values, a compilation of CS2 ice thicknesses, Bedmap-2 ice thicknesses, and IPR track measurements from the IceBridge project.
Dashed lines are calculated using Eq. (2) with an assigned β-value of 0.7.
Accordingly, the intensities of the He I lines are calculated using CR model-based data from the ADAS database.
Each OATP1B3 expression level (copies/ng total RNA) in colon tissues, lung tissues, and cancer cell lines was calculated using its corresponding standard curve based on the condition that the mRNA expression level below 103 copies/ng total RNA, which was regarded as the level below the quantification limit (QL), the qPCR Ct-value of which was over 35.
The copy number of the CD97 transgene in the genome of these lines was calculated using real-time PCR.
The minimal distance from each "case/control" site to its nearest points or lines was calculated, using point-type or line-type information (i.e., wetlands, transportation routes including railways, freeways and national highways, migration routes and main cities).
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