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Patients were heavily pretreated (mean 4.5 lines of therapy).
Disease courses are typically characterized by multiple relapses and progressively shorter response duration with subsequent lines of therapy.
Twenty-four (75%) patients were Durie Salmon stage III, and 12 (37.5%) had >2 prior lines of therapy.
Moreover, the majority of patients will require multiple lines of therapy as their cancer cells acquire resistance to the chemotherapeutic agents to which they are exposed.
However, the outcomes with standard chemotherapy over sequential lines of therapy in a large cohort of patients with BRAF-mutant tumors have not been described.
The differential impact of the number of prior lines of therapy and the setting of prior therapy (perioperative or metastatic) is unclear in advanced urothelial carcinoma.
For high-risk CLL an allo-HCT is recommended after failing 2 lines of therapy and showing an objective response to BCR inhibitors or to a clinical trial.
This is especially crucial in the management of young, fit patients, who may be suitable candidates for two or more lines of therapy.
We focused mainly on HAGlow miRNAs, which are presumably tumor-suppressive and could provide the basis for novel lines of therapy for melanoma.
Patients often received several lines of therapy.
All lines of therapy were well tolerated.
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