Although alternative SSX fusions and various lines of differentiation can be demonstrated in SS [ 29, 30], they display homogenous and distinct expression profiles that enable clear distinction from other STS subtypes [ 4, 9, 10, 12, 19, 20] and our finding of 4000 differentially expressed genes is in line with these results.
Dahlin and Beabout (1971) reported the term 'dedifferentiation', which is the progression of cells towards a less differentiated state with no longer the original line of differentiation.
The term 'dedifferentiation' has been reported as a progression of cells towards a less differentiated state with no longer the original line of differentiation (Dahlin and Beabout, 1971).
Theologically, the articles meant to draw a line of differentiation from the psition of Huldrych Zwingli, and they were accepted by the secular leaders of Saxony and Brandenburg.
Some pancreatic neoplasms have significant components from more than one line of differentiation and are classified as mixed acinar-endocrine carcinomas (MAEC), mixed acinar-ductal carcinomas, mixed ductal-endocrine carcinomas, or mixed acinar-endocrine-ductal carcinomas [2].
Based on their presumed histogenesis and their line of differentiation, a practical classification system for clinical purposes has been adopted (Mostofi and Sobin, 1997; Rosai, 2004).
Undifferentiated pleomorphic sarcoma (UPS) showing no identifiable line of differentiation is a heterogeneous tumor group as defined by the World Health Organization (WHO) classification [ 1].
The basic principle for the diagnosis of soft tissue sarcomas is to find the specific line of differentiation and not to throw tumors into the "wastebasket" of UPS [ 24, 25].
In mammals, the division between the cortex and the medulla of the ovary is fluid [ 57] and the line of differentiation is set halfway between the occurrence of follicles in the cortex and the blood vessels in the medulla [ 55].
The pathologist's approach to definitive diagnosis of the patient with metastasis of unknown primary effectively followed a few sequential steps: First of all we tried to determine the cell line of differentiation e.g. carcinoma, lymphoma, melanoma, sarcoma, or germ cell, with the help of morphological findings and if needed, immunohistochemical stains.
Furthermore, P-cadherin expression was positive in all mucinous carcinomas and carcinosarcomas a fact that points to a basal/myoepithelial cell histogenesis origin or line of differentiation of these tumour types [ 16, 60, 61], since P-cadherin is a well-recognized biomarker of basal mammary carcinomas in humans [ 6, 62- 65].
