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Similar results were observed in human liver cancer cell lines (data not shown).
A similar reduction in telomere length was also observed with other MM cell lines (data not shown).
Of note, β-catenin siRNA knockdown alone (for 72 hours) did not significantly affect the cell growth of both cell lines (data not shown).
We have tried mitoSOX for mitochondrial superoxides detection but did not detect differences between control and patient cell lines (data not shown).
Inhibition of telomerase activity following treatment with 1 μM GRN163L was also seen for MM1S and OPM1 myeloma cell lines (data not shown).
These results were reproducible in other OS cell lines (data not shown).
High levels of SUFU transcript were exhibited by these polyclonal lines (data not shown).
Similar results were obtained in three separate CHIP shRNA stable cell lines (data not shown).
No foci containing the endogenous RNAs were detected in these lines (data not shown).
Similar results were obtained with the three other pancreatic tumour cell lines (data not shown).
EGR1 was up-regulated by γ-secretase inhibitor in human osteosarcoma cell lines (data not shown).
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